Love all the tools mentioned in the comments, Pyodide is a fun tool. I built https://pyground.vercel.app with it a few years ago, as a quick way to run Python on a CSV/JSON file locally in the browser. For a while Python/Matplotlib was what I was most comfortable writing quick and simple analysis scripts with, and this was my go to for one-off data analysis work. You can drag-drop a file in, then some 'clever' code makes it available as `data` in the Python script so you don't have to write any parsing code yourself.

Now I'd probably just get Claude Code to write something locally, but there might be some value in a version of pyground that can use an LLM to write the Python code for you (and give it the data shape) but keeps the local execution setup the same.